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Poole is faithful servant of Dr. Jekyll and has nothing but love for his master. He shows tremendous concern for Jekyll when he locks himself in his laboratory. He visits all the chemists in town on his master's instructions, in search of the drugs he needs. When he feels that his master's life is in danger, he immediately rushes to Utterson for help. Poole is not as educated as Utterson, and thus, in Utterson's eyes, is more likely to be subject to superstitious fears, but Poole manages to convince Utterson to break down the laboratory door, something he, as a servant, could not properly do himself. Of course, Poole is right; something has happened to Jekyll, though neither he nor Utterson could possibly guess exactly what has happened. Thus, Poole has some admirable virtues by which he endears himself to his master and to the reader
Guest is Utterson's chief clerk and a handwriting expert. He points out the strong similarity between Jekyll's and Hyde's handwriting, taking the reader deeper into the mystery. He and Utterson trust each other, yet, despite sharing confidences, they are both discreet in their conversation, saying no more than what is absolutely necessary to each other. Utterson does not mention his fear for Jekyll, and Guest does not accuse Jekyll of forgery or worse, yet each man knows what the other is thinking. Their entire scene together is a masterpiece of understatement and inference.